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| Cat.No | ACP24711 | Target Name | NRTN |
|---|---|---|---|
| Target Synonyms | Neurturin; Neurturin precursor; NRTN; NRTN_HUMAN; NTN; prepro-neurturin | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Mol Weight | 23.4 kDa |
| Purity | >96% as determined by SDS-PAGE and HPLC. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q99748 |
|---|
Uniprot Id
Q99748
Target Species
Human
Target Name
NRTN
Target Full Name
Neurturin
Target Function
Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells.
Target Involvement
Genetic variations in NRTN may contribute to Hirschsprung disease, in association with mutations of RET gene, and possibly mutations in other loci. Hirschsprung disease is a disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction.
Target Subcellular Location
Secreted.
Target Protein Families
TGF-beta family, GDNF subfamily
Target Synonyms
Neurturin; Neurturin precursor; NRTN; NRTN_HUMAN; NTN; prepro-neurturin
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