Recombinant human Keratin, type II cytoskeletal 8 protein

Uniprot Id

P05787

Target Species

Human

Target Name

KRT8

Target Full Name

Keratin, type II cytoskeletal 8

Target Function

Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.

Target Involvement

Cirrhosis (CIRRH)

Target Subcellular Location

Cytoplasm. Nucleus, nucleoplasm. Nucleus matrix.

Target Protein Families

Intermediate filament family

Target Tissue Specificity

Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity.

Target Research Area

Immunology, Signal Transduction

Target Synonyms

CARD2; CK 8; CK-8; CK8; CYK8; CYKER; Cytokeratin endo A; Cytokeratin-8; DreK8; EndoA; K2C8; K2C8_HUMAN; K8; Keratin 8; Keratin type II cytoskeletal 8 ; Keratin; type II cytoskeletal 8; Keratin-8; KO; Krt 2.8; KRT8; MGC118110; MGC174782; MGC53564; MGC85764; sb:cb186; Type-II keratin Kb8

Target Background

This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene.