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The antibody against SPPL2B was raised in rabbit using the Recombinant Human Signal peptide peptidase-like 2B protein (492-592AA) as the immunogen. This antibody exists as a biotin conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
The antibody against SPPL2B was raised in rabbit using the Recombinant Human Signal peptide peptidase-like 2B protein (492-592AA) as the immunogen. This antibody exists as a biotin conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
$299.00
| Cat.No | ADC-03934A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SPPL2B |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Biotin conjugated |
| Application | ELISA | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Signal peptide peptidase-like 2B protein (492-592AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | and peptides are available upon request., Complete sequences for the immunogen, target protein | Uniprot ID | Q8TCT7 |
Uniprot Id
Q8TCT7
Target Species
Human
Target Name
SPPL2B
Target Full Name
Signal peptide peptidase-like 2B
Target Function
Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in ITM2B and TNF processing. Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus. May play a role in the regulation of innate and adaptive immunity. Catalyzes the intramembrane cleavage of the simian foamy virus processed leader peptide gp18 of the envelope glycoprotein gp130 dependently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis.
Target Subcellular Location
Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein; Lumenal side.
Target Protein Families
Peptidase A22B family
Target Tissue Specificity
Expressed predominantly in adrenal cortex and mammary gland.
Target Synonyms
SPPL2B; IMP4; KIAA1532; PSL1; Signal peptide peptidase-like 2B; SPP-like 2B; SPPL2b; EC 3.4.23.-; Intramembrane protease 4; IMP-4; Presenilin homologous protein 4; PSH4; Presenilin-like protein 1
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